Structural requirements for catalysis by chorismate mutase

…, RE Padykula, JD Kronis, RA Aleksejczyk…

Index: Pawlak, John L.; Padykula, Robert E.; Kronis, John D.; Aleksejczyk, Robert A.; Berchtold, Glenn A. Journal of the American Chemical Society, 1989 ,  vol. 111,  # 9  p. 3374 - 3381

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Citation Number: 43

Abstract

Abstract: The structural requirements for mutase-catalyzed Claisen rearrangement by chorismate mutase-prephenate dehydrogenase from Escherichia coli have been established. The chorismate analogue lacking the carboxyl group at Ci (5) was not a substrate for chorismate mutase. The methyl ether of chorismate [(f)-6] was a good substrate for chorismate mutase (kCBt/kUnCBt= 2.0 X lo4). The half-lives for Claisen rearrangement ...