A Practical Synthesis of Optically Active (R)-2-Propyloctanoic Acid: Therapeutic Agent for Alzheimer's Disease.

T Hasegawa, H Yamamoto

Index: Hasegawa, Tomoyuki; Yamamoto, Hisashi Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 2 p. 423 - 428

Full Text: HTML

Citation Number: 56

Abstract

(R)-2-Propyloctanoic acid has been developed as a novel therapeutic agent for Alzheimer's disease. A large-scale synthesis of this candidate was achieved by using Oppolzer's camphorsultam as a chiral auxiliary under improved conditions. It was essential for the successful synthesis of this compound to utilize a new removal method for the chiral source with a combination of tetrabutylammonium hydroxide and hydrogen peroxide. The present ...