Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2

…, G Rajakumar, LK Srivastava, RK Mishra…

Index: Yu, Kuo-Long; Rajakumar, G.; Srivastava, Lalit K.; Mishra, Ram K.; Johnson, Rodney L. Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1430 - 1436

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Citation Number: 88

Abstract

3 (R)-amino-2-oxopyrrolidineacetamide and the d-lactam residue 3 (S)-amino-2- oxopiperidineacetamide. The corresponding y-lactam analogues of< Glu-Leu-Gly-NHz were also synthesized. In a second series of analogues, the glycinamide residue of PLG was replaced with the 2-ketopiperazine, 3 (S)-amino-2-pyrrolidone, and 3 (S)-amino-2- piperidone residues. The above analogues were tested for their ability to enhance the ...