Novel Tricyclic Indeno [5, 6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity

…, LJ Yang, Y Li, XQ Wang, SJ Wang…

Index: Chen, Wen; Yang, Li-Juan; Li, Yan; Wang, Xue-Quan; Wang, Shao-Jie; Wan, Wei-Chao; Zhang, Hong-Bin; Yang, Xiao-Dong Letters in Drug Design and Discovery, 2013 , vol. 10, # 7 p. 561 - 571

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Citation Number: 3

Abstract

A series of novel hybrid compounds between tricyclic indeno [5, 6-b] furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3- position with a naphthylacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 26 was found to be the most potent compound against 5 strains human ...