Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes

SL Iverson, L Shen, N Anlar…

Index: Iverson, Suzanne L.; Shen, Li; Anlar, Nilgun; Bolton, Judy L. Chemical Research in Toxicology, 1996 , vol. 9, # 2 p. 492 - 499

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Citation Number: 104

Abstract

Although the carcinogenic effects of estrogens have been mainly attributed to hormonal properties, there is interest in estrogens acting as chemical carcinogens by binding to cellular macromolecules. In the present study, we explored factors which influence the rate of P450-catalyzed formation of the o-quinones (3, 5-cyclohexadiene-1, 2-diones) from 2- hydroxyestrone (2-OHE) and 4-hydroxyestrone (4-OHE) as well as from estrone in rat liver ...