Sodium borohydride: A versatile reagent in the reductive N-monoalkylation of α-amino acids and α-amino methyl esters

G Verardo, P Geatti, E Pol…

Index: Verardo, Giancarlo; Geatti, Paola; Pol, Elena; Giumanini, Angelo G. Canadian Journal of Chemistry, 2002 , vol. 80, # 7 p. 779 - 788

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Citation Number: 23

Abstract

α-Amino acids and α-amino methyl esters are easily converted to their N-monoalkyl derivatives by a reductive condensation reaction using several carbonyl compounds in the presence of sodium borohydride. This reducing agent has shown a wide versatility with minor but essential procedural variations. The reaction allows the α-monodeuterium labeling of the new N-substituent by use of sodium borodeuteride. Key words: α-amino acid, α- ...

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