Tetrahedron Letters

Synthesis of 3-methyleneisoindolin-1-ones via palladium-catalyzed C–Cl bond cleavage and cyclocarbonylation of ortho-chloro ketimines

J Ju, C Qi, L Zheng, R Hua

Index: Ju, Jia; Qi, Chuanmei; Zheng, Liyao; Hua, Ruimao Tetrahedron Letters, 2013 , vol. 54, # 38 p. 5159 - 5161

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Citation Number: 7

Abstract

Abstract PdCl 2 (PCy 3) 2-catalyzed cyclocarbonylative coupling of ortho-chloro arylketimines with CO has been investigated to develop an efficient method for the synthesis of isoindolin-1-ones. The developed synthetic method has the advantages of having easily available starting materials, high atom-economy, and high selectivity.

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