First Asymmetric Total Synthesis of (R, E)-1-[4-(3-Hydroxyprop-1-enyl) phenoxyl]-3-methylbutane-2, 3-diol

…, K Rajesh, JJP Selvam, Y Venkateswarlu

Index: Suresh; Rajesh; Selvam; Venkateswarlu Synthetic Communications, 2011 , vol. 41, # 7 p. 993 - 998

Full Text: HTML

Citation Number: 0

Abstract

Abstract A new anti-inflammatory active phenylpropenoid,(R, E)-1-[4-(3-hydroxyprop-1-enyl) phenoxyl]-3-methylbutane-2, 3-diol (1), isolated from the stem wood of Zanthoxylum integrifoliolum, has been synthesized for the first time using commercially available 4- hydroxy benzaldehyde (2). The key step involves the Sharpless asymmetric dihydroxylation of olefin (3).