Synthesis and Evaluation of Novel 2, 3??Dihydrobenzo [b][1, 4] dioxin??and Indolealkylamine Derivatives as Potential Antidepressants

S Wang, Y Chen, X Liu, X Xu, X Liu, BF Liu…

Index: Liu, Xin; Wang, Songlin; Chen, Yin; Liu, Xinghua; Xu, Xiangqing; Liu, Bi-Feng; Zhang, Guisen Archiv der Pharmazie, 2014 , vol. 347, # 1 p. 32 - 41

Full Text: HTML

Citation Number: 3

Abstract

Abstract A series of 2, 3-dihydrobenzo [b][1, 4] dioxin-and indolealkylamine derivatives were synthesized and the target compounds were evaluated for their binding affinities at the 5-HT 1A receptor and serotonin transporter. Antidepressant-like activities of the compounds were screened using the tail suspension and forced swim tests in mice. Preliminary results indicated that the target compounds exhibited high binding affinities at the 5-HT 1A ...