A new approach to bicyclomycin

…, JA Gregory, RB Herbert, PG Sammes

Index: Dawson, Ian M.; Gregory, Julian A.; Herbert, Richard B.; Sammes, Peter G. Journal of the Chemical Society, Chemical Communications, 1986 , # 8 p. 620 - 621

Full Text: HTML

Citation Number: 5

Abstract

A simple route to the bicyclomycin nucleus (2) is described which involves use of a P-vinyl sulphone as a new vinylic cation synthon. ... Bicyclomycin (1), which is currently used as an antibiotic in animal foodstuff,l has been the subject of several recent synthetic studies.2.3 Herein we describe an alternative, novel and short synthesis of the key intermediate (2), which has been used in the total synthesis of bicyclomycin.3 Retrosynthetic analysis of the structure of the ...

Related Articles:

Synthesis of (1-halo-1-alkenyl) trimethylsilanes via gem-trimethylsilylation of vinyl halides.

[Bulletin of the Chemical Society of Japan, , vol. 60, # 2 p. 777 - 778]

1-Bromo-1-lithioethene: A Practical Reagent for the Efficient Preparation of 2-Bromo-1-alken-3-ols

[Organic Letters, , vol. 5, # 13 p. 2263 - 2266]

Synthesis of (1-halo-1-alkenyl) trimethylsilanes via gem-trimethylsilylation of vinyl halides.

[Bulletin of the Chemical Society of Japan, , vol. 60, # 2 p. 777 - 778]

Synthesis of alkenes from carbonyl compounds and carbanions. alpha. to silicon. 6. Synthesis of terminal allenes and allyl chlorides

[Journal of Organic Chemistry, , vol. 43, p. 1526 - 1532]

Erzeugung und Reaktionen von α??(Trimethylsilyl)??, α??(Phenylthio)??und α??(Phenylseleno) vinyllithium??Verbindungen

[Chemische Berichte, , vol. 110, p. 867 - 877]

More Articles...