Synthesis of 2′??Substituted MMI Linked Nucleosidic Dimers: An Optimization Study in Search of High Affinity Oligonucleotides for Use in Antisense Constructs

…, EE Swayze, B Bhat, YS Sanghvi

Index: Swayze, Eric E.; Sanghvi, Yogesh S. Synlett, 1997 , vol. 1997, # 7 p. 859 - 861

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Citation Number: 7

Abstract

The synthesis of a series of methylene (methylimino)(MMI) linked oligodeoxyribonucleotide dimers modified at the 2′??position with fluoro and/or methoxy groups and their incorporation into different sequences has been accomplished. From these dimers, bis 2′??