An efficient protocol for regioselective ring opening of epoxides using sulfated tungstate: application in synthesis of active pharmaceutical ingredients atenolol, …

SP Pathare, KG Akamanchi

Index: Pathare, Sagar P.; Akamanchi, Krishnacharya G. Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6455 - 6459

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Citation Number: 12

Abstract

Abstract Sulfated tungstate was found to be a new and highly efficient catalyst for opening of epoxide rings by amines to give β-amino alcohols with high regioselectivity. Various advantages associated with this novel and environmental friendly protocol include solvent- free conditions, short reaction times, high product yields, simple workup procedure and easy recovery and reusability of the catalyst. This protocol has been applied for the synthesis of ...