Synthesis and antimicrobial and nitric oxide synthase inhibitory activities of novel isothiourea derivatives

…, R Moo-Puc, R Cedillo-Rivera, BJ Starosciak…

Index: Kazimierczuk, Zygmunt; Chalimoniuk, Malgorzata; Laudy, Agnieszka Ewa; Moo-Puc, Rosa; Cedillo-Rivera, Roberto; Starosciak, Bohdan Jerzy; Chrapusta, Stanislaw J. Archives of Pharmacal Research, 2010 , vol. 33, # 6 p. 821 - 830

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Citation Number: 17

Abstract

Abstract The reaction of substituted benzylhalides, or of halomethyl derivatives of thiophene or furane, with thiourea or its derivatives yielded the respective isothioureas as hydrohalide salts. The products (a total of 17, including 16 novel compounds) were tested for activity against five Gram-positive and nine Gram-negative bacterial strains, six yeast species and two protozoan species. The most active against Gram-positive bacteria were S-(2, 4- ...