Discovery of a potent, peripherally selective trans-3, 4-dimethyl-4-(3-hydroxyphenyl) piperidine opioid antagonist for the treatment of gastrointestinal motility disorders

DM Zimmerman, JS Gidda, BE Cantrell…

Index: Journal of Medicinal Chemistry, , vol. 37, # 15 p. 2262 - 2265

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Citation Number: 127

Abstract

... The strategy involved increasing both the size and polarity of the N-substitutent in the arylpiperidine 2. Previous SAR findings provided direction in the 0 1994 American Chemical Society ... Potent Opioid Antagonist Journal of Medicinal Chemistry, 1994, Vol. 37, No. ...