Tetrahedron

Zr-promoted 'pair'-selective and regioselective synthesis of penta-substituted benzene derivatives

YR Dumond, E Negishi

Index: Dumond, Yves R.; Negishi, Ei-Ichi Tetrahedron, 2004 , vol. 60, # 6 p. 1345 - 1352

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Citation Number: 10

Abstract

Tetra-substituted zirconacyclopentadiene derivatives, obtainable via in situ generation of zirconacyclopropenes and their cyclic carbozirconation with alkynes, can be treated with alkynyllithiums to induce 1, 2-migration accompanied by aromatization and protonolysis, leading to the formation of penta-substituted benzene derivatives, in which all five substituted may be different.