Tetrahedron: Asymmetry

Practical synthesis of (3S, 4S)-3-methoxy-4-methylaminopyrrolidine

Y Tsuzuki, K Chiba, K Mizuno, K Tomita…

Index: Tsuzuki, Yasunori; Chiba, Katsumi; Mizuno, Kazuhiro; Tomita, Kyoji; Suzuki, Kenji Tetrahedron Asymmetry, 2001 , vol. 12, # 21 p. 2989 - 2997

Full Text: HTML

Citation Number: 27

Abstract

Three synthetic methods for the preparation of (3S, 4S)-3-methoxy-4-methylaminopyrrolidine , an important intermediate in the synthesis of the novel quinolone antitumor agent, AG- 7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (±)-1-Boc-3-benzylamino-4- hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1, 4-dichloro-2-butene.

Related Articles:

Silica supported perchloric acid (HClO 4–SiO 2): an efficient reagent for the preparation of primary carbamates under solvent-free conditions

[Modarresi-Alam, Ali Reza; Khamooshi, Ferydoon; Nasrollahzadeh, Mahmoud; Amirazizi, Homeyra Alsadat Tetrahedron, 2007 , vol. 63, # 36 p. 8723 - 8726]

New Methods of Introducing the Carbo-t-butoxy Protective Group. Preparation of t-Butyl Cyanoformate1

[Carpino,L.A. Journal of the American Chemical Society, 1960 , vol. 82, p. 2725 - 2727]

New Methods of Introducing the Carbo-t-butoxy Protective Group. Preparation of t-Butyl Cyanoformate1

[Carpino,L.A. Journal of the American Chemical Society, 1960 , vol. 82, p. 2725 - 2727]

Decomposition of sulfonyl azides and tert-butyl azidoformate by transition metal carbonyls

[Abramovitch,R.A. et al. Journal of Organic Chemistry, 1974 , vol. 39, p. 2513 - 2516]

New Methods of Introducing the Carbo-t-butoxy Protective Group. Preparation of t-Butyl Cyanoformate1

[Carpino,L.A. Journal of the American Chemical Society, 1960 , vol. 82, p. 2725 - 2727]

More Articles...