Unexpected C O bond formation in Suzuki coupling of 4??chlorothieno [2, 3??d] pyrimidines

E Perspicace, S Hesse, G Kirsch…

Index: Perspicace, Enrico; Hesse, Stephanie; Kirsch, Gilbert; Yemloul, Mehdi; Lecomte, Claude Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 459 - 464

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Citation Number: 11

Abstract

Kinase insert domain (KDR)-containing receptor is one of the human tyrosine kinases that has a high affinity for vascular endothelial growth factor (VEGF) and is believed to be a primary mediator of tumor-induced angiogenesis [1]. Compounds which influence the KDR kinase have attracted much attention and are of great interest as potential therapeutic agents. Several compounds with a quinazoline moiety have shown effective antitumor ...

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