Alkylsulfanyl-1, 2, 4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure–activity relationships

P Polucci, P Magnaghi, M Angiolini, D Asa…

Index: Journal of Medicinal Chemistry, , vol. 56, # 2 p. 437 - 450

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Citation Number: 34

Abstract

... Journal of Medicinal Chemistry. ... Nerviano Medical Sciences Srl ... This, together with the difficulty encountered in attempts to obtain cocrystals suitable for X-ray diffraction, led us to undertake medicinal chemistry optimization through a traditional iterative SAR approach. ...

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1, 3, 4] thiadiazolo [3, 2-a] pyrimidin-5-one derivatives

[Sathisha; Khanum, Shaukath A.; Chandra, J.N. Narendra Sharath; Ayisha; Balaji; Marathe, Gopal K.; Gopal, Shubha; Rangappa Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 211 - 220]

Alkylsulfanyl-1, 2, 4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure–activity relationships

Abstract

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