Synthesis of imidazo [1, 2-a] pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

C Sablayrolles, JC Milhavet, E Rechenq…

Index: Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212

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Citation Number: 50

Abstract

A series of imidazo [1, 2-a] pyrazine derivatives was synthesized by condensation of a- halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo-[1, 2-a] pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an ...