Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues

S Levesque, Y St-Denis, B Bachand, P Preville…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 24 p. 3161 - 3164

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Citation Number: 14

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... We planned to compensate for this reduction in potency by incorporating additional chemical features in the inhibitors, primarily through introduction of various P1 residues. ...

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