Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin

…, S Yang, X Wu, E Studer, E Gurley, PB Hylemon…

Index: Liang, Guang; Li, Xiaokun; Chen, Li; Yang, Shulin; Wu, Xudong; Studer, Elaine; Gurley, Emily; Hylemon, Phillip B.; Ye, Faqing; Li, Yueru; Zhou, Huiping Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 4 p. 1525 - 1529

Full Text: HTML

Citation Number: 86

Abstract

Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The β-diketone moiety renders curcumin to be rapidly metabolized by aldo–keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an ...

Related Articles:

1, 5-Diphenyl-1, 4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship

[Sardjiman; Reksohadiprodjo; Hakim; Van Der Goot; Timmerman European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 625 - 630]

Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling

[Journal of Medicinal Chemistry, , vol. 41, # 21 p. 3948 - 3960]

Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling

[Journal of Medicinal Chemistry, , vol. 41, # 21 p. 3948 - 3960]

Anti-oxidant activities of curcumin and related enones

[Bioorganic and Medicinal Chemistry, , vol. 13, # 11 p. 3811 - 3820]

More Articles...