Development of new HPLC chiral stationary phases based on native and derivatized cyclofructans

P Sun, C Wang, ZS Breitbach, Y Zhang…

Index: Sun, Ping; Wang, Chunlei; Breitbach, Zachary S.; Zhang, Ying; Armstrong, Daniel W. Analytical Chemistry, 2009 , vol. 81, # 24 p. 10215 - 10226

Full Text: HTML

Citation Number: 111

Abstract

An unusual class of chiral selectors, cyclofructans, is introduced for the first time as bonded chiral stationary phases. Compared to native cyclofructans (CFs), which have rather limited capabilities as chiral selectors, aliphatic-and aromatic-functionalized CF6s possess unique and very different enantiomeric selectivities. Indeed, they are shown to separate a very broad range of racemic compounds. In particular, aliphatic-derivatized CF6s with a low ...