A convenient protection for 4-oxopyrimidine moieties in nucleosides by the pivaloyl group

M Sobkowski

Index: Sobkowski, Michal Collection of Czechoslovak Chemical Communications, 2010 , vol. 75, # 1 p. 33 - 57

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Abstract

Abstract Application of the pivaloyl group as a protection for the N3 position of thymidine and uridine was investigated. Pivaloylation of thymidine is a very rapid reaction proceeding under mild conditions with excellent regioselectivity for sugar or thymine moiety, depending on the amines used. Several pivaloylated thymidine derivatives were obtained by treatment of unprotected thymidine with pivaloyl chloride under various experimental conditions. ...

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