Improved Preparation of 5-Chloro-1-phenyl-1 H-tetrazole and Other 5-Chlorotetrazoles.

JAC Alves, RAW Johnstone

Index: Alves, Jose A.C.; Johnstone, Robert A.W. Synthetic Communications, 1997 , vol. 27, # 15 p. 2645 - 2650

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Citation Number: 11

Abstract

Abstract Reaction of aryldichloroisocyanides 1a–e with sodium azide and a phase transfer agent has provided 5-chloro-1-aryl-1 H-tetrazoles 2a–e in good yield. In particular, the widely-used intermediate, 5-chloro-1-phenyl-1 H-tetrazole 2a, can be produced conveniently and safely in yields approaching 100%.