A Pyrimidopyrimidine Janus??AT Nucleoside with Improved Base??Pairing Properties to both A and T within a DNA Duplex: The Stabilizing Effect of a Second …

E Largy, W Liu, A Hasan…

Index: Largy, Eric; Liu, Wenbo; Hasan, Abid; Perrin, David M. Chemistry - A European Journal, 2014 , vol. 20, # 6 p. 1495 - 1499

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Abstract

Abstract Janus bases are heterocyclic nucleic acid base analogs that present two different faces able to simultaneously hydrogen bond to nucleosides that form Watson–Crick base pairs. The synthesis of a Janus-AT nucleotide analogue, NJ AT, that has an additional endocyclic ring nitrogen and is thus more capable of efficiently discriminating T/A over G/C bases when base-pairing in a standard duplex-DNA context is described. Conversion to a ...

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