Tetrahedron letters

A convenient cross-coupling route to α, β, γ, δ-unsaturated amino acids

MJ Burk, JG Allen, WF Kiesman, KM Stoffan

Index: Burk, Mark J.; Allen, John G.; Kiesman, William F.; Stoffan, Karen M. Tetrahedron Letters, 1997 , vol. 38, # 8 p. 1309 - 1312

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Citation Number: 30

Abstract

β-Bromoenamide esters are coupled stereospecifically to vinylboronic acids via a palladium- catalyzed Suzuki reaction. This cross-coupling proceeds under mild conditions with Pd (OAc) 2 in 95% EtOH at 50° C and produces amino acids with 1, 3-diene side chains in high yields.

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