Hydroxylation of Androst-4-ene-3, 17-dione with the Aid of Curvularia Lunata Fungus

SD Shuvalova, KN Gabinskaya, EV Popova…

Index: Shuvalova; Gabinskaya; Popova; Savinova; Andryushina Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 5 p. 279 - 281

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Abstract

As is known, Curvularia lunata fungus is capable of introducing a hydroxy group at the 11β position of steroidal molecules [1] or at the 14α position of compounds of the androstane series [2, 3]. The process of 11β-hydroxylation of pregnanes (for example, of cortexolone and its derivatives), which is widely used in the commercial synthesis of corticosteroid drugs, has been studied in sufficient detail. In particular, it is known that the target product yield ...

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