An expedient, scalable synthesis of the natural product L-anserine

C Wiles, P Watts

Index: Wiles, Charlotte; Watts, Paul Synthesis, 2007 , # 17 p. 2608 - 2610

Full Text: HTML

Citation Number: 5

Abstract

Abstract To date, the synthesis of l-anserine has relied on the use of naturally occurring 1- methyl-l-histidine as a precursor, however its high cost prevents its use in the large-scale synthesis of l-anserine. With this in mind, we report herein a concise and efficient synthetic strategy, employing the 160-fold less expensive, l-histidine methyl ester dihydrochloride as a starting material, to afford the title compound in an overall yield of 88%, over four reaction ...