Journal of enzyme inhibition and medicinal chemistry

Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1 H-benzo [d] imidazol-2 (3 H)-ones

N Ullah

Index: Ullah, Nisar Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 2 p. 281 - 291

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Citation Number: 7

Abstract

Abstract A series of new 5-piperidinyl and 5-piperazinyl-1 H-benzo [d] imidazol-2 (3 H)-ones have been synthesized and evaluated for dual D2 and 5-HT1A receptor binding affinities. The synthesized ligands are structurally related to bifeprunox, a potential atypical antipsychotic, having potent D2 receptor antagonist and 5-HT1A receptor agonist properties. The Suzuki–Miyaura reaction of cyclic vinyl boronate with appropriate aryl halide yielded ...