Il Farmaco

Synthesis of novel N-substituted imidazolecarboxylic acid hydrazides as monoamine oxidase inhibitors

F Hadizadeh, R Ghodsi

Index: Hadizadeh, Farzin; Ghodsi, Razieh Farmaco, 2005 , vol. 60, # 3 p. 237 - 240

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Citation Number: 7

Abstract

Novel 2-alkylsulfanyl-1-benzyl-5-imidazolecarboxylic acid hydrazides (15a, b) were synthesized as analogues of isocarboxazide, which is a known nonselective irreversible monoamine oxidase inhibitor and tested for monoamine oxidase A and B inhibitory activity. Neither of the compounds showed any inhibition of MAO B activity up to a high concentration of 100 μM. An MAO A activity was only slowly inhibited at this high concentration after ...