Function??Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing

RD Carpenter, AS Verkman

Index: Carpenter, Richard D.; Verkman, Alan S. European Journal of Organic Chemistry, 2011 , # 7 p. 1242 - 1248

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Citation Number: 4

Abstract

Abstract Triazacryptand (TAC)-based fluorescent K+ sensors have broad biomedical utility, yet their advancement has been hindered because of their challenging synthesis. Herein, an efficient synthesis is reported that delivers a didesmethyl triazacryptand (ddTAC) K+ sensor in twofold fewer steps and ninefold higher overall yield than the original TAC synthesis. Our synthesis utilizes a C–O dianionic oxidative macrocyclization and reports new examples ...