Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation
P Basabe, M de Roman, IS Marcos, D Diez…
Index: Basabe; De Roman; Marcos; Diez; Blanco; Bodero; Mollinedo; Sierra; Urones European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 4258 - 4269
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Citation Number: 17
Abstract
Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more ...
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