The Journal of Organic Chemistry

. alpha.,. alpha.-Difluoroarylacetic acids: preparation from (diethylamino) sulfur trifluoride and. alpha.-oxoarylacetates

WJ Middleton, EM Bingham

Index: Middleton, W. J.; Bingham, E. M. Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2883 - 2887

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Citation Number: 114

Abstract

Several a, a-difluoroarylacetic acids have been prepared by reaction of DAST ((diethy1amino) sulfur trifluoride) with esters of a-oxoarylacetic acids and then hydrolysis of the resulting difluoro ester. Examples include the a, a-difluoro derivatives of the synthetic plant auxin, a-naphthylacetic acid, and the antiinflammatory drug, ibufenac.

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