O??Glycoside Orientation Is an Essential Aspect of Base J Recognition by the Kinetoplastid DNA??Binding Protein JBP1

…, P Subramaniam, DA Case, DP Millar…

Index: Grover, Rajesh K.; Pond, Stephanie J. K.; Cui, Qizhi; Subramaniam, Prem; Case, David A.; Millar, David P.; Wentworth Jr., Paul Angewandte Chemie - International Edition, 2007 , vol. 46, # 16 p. 2839 - 2843

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Citation Number: 20

Abstract

Leishmaniasis (cutaneous or visceral, Leishmania sp.), African trypanosomiasis (sleeping sickness, Trypanosoma brucei), and American trypanosomiasis (Chagas disease, T. cruzi) are devastating diseases in the developing world. Present pharmaceuticals against these parasites are limited in terms of effectiveness, increasing drug resistance, and inherent drug toxicity. Therefore, there is a clear need for elucidation of parasite-specific biological ...