2??Amino??2′??desoxytubercidin und verwandte Pyrrolo [2, 3??d] pyrimidinyl??2′??desoxyribofuranoside

F Seela, H Steker, H Driller…

Index: Seela, Frank; Steker, Herbert; Driller, Hansjuergen; Bindig, Uwe Liebigs Annalen der Chemie, 1987 , p. 15 - 19

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Citation Number: 29

Abstract

Abstract Phasentransferglycosylierung von 2-Amino-4-chlor-7H-pyrrolo-[2, 3-d] pyrimidin (4a) mit 1-Chlor-3, 5-di-O-(p-toluoyl)-α-D-erythro-pentofuranose (7) führt regio-und diastereoselektiv zum kristallinen Verknüpfungsprodukt 5a. Dessen 4-Halogensubstituent oder der des ungeschützten Nucleosids 2b ist nucleophil substituierbar, wodurch 2-Amino- 2′-desoxytubercidin (1) und das Thionucleosid 3a zugänglich werden. In Abwesenheit ...

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