Emulation of racemase activity by employing a pair of stereocomplementary biocatalysts

…, BM Nestl, J Gross, P Hildebrandt…

Index: Gruber, Christian C.; Nestl, Bettina M.; Gross, Johannes; Hildebrandt, Petra; Bornscheuer, Uwe T.; Faber, Kurt; Kroutil, Wolfgang Chemistry - A European Journal, 2007 , vol. 13, # 29 p. 8271 - 8276

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Citation Number: 19

Abstract

Abstract Racemization is the key step to turn a kinetic resolution process into dynamic resolution. A general strategy for racemization under mild reaction conditions by employing stereoselective biocatalysts is presented, in which racemization is achieved by employing a pair of stereocomplementary biocatalysts that reversibly interconvert an sp 3 to a sp 2 center. The formal interconversion of the enantiomers proceeds via a prochiral sp 2 intermediate ...

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