The Journal of organic chemistry

Cap-and-tag solid phase oligosaccharide synthesis

FR Carrel, PH Seeberger

Index: Carrel, Frederic R.; Seeberger, Peter H. Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2058 - 2065

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Citation Number: 29

Abstract

A new “cap-and-tag” strategy is applied to solid phase oligosaccharide synthesis. Acetyl- capping and fluorous-tagging allowed for the facile separation of the desired F-tagged oligosaccharide from the acetyl-capped deletion sequences using fluorous solid phase extraction. To illustrate this approach, a protected Glc-β-(1→ 6)-Man-α-(1→ 6)-Glc-β-1→ pentenyl trisaccharide was synthesized.

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