New oxidation of β-hydroxy α-methyl ketones: a convenient synthesis of 3-methylalkane-2, 4-diones
Y Yuasa, Y Kato
Index: Yuasa, Yoshifumi; Kato, Yasushi Organic Process Research and Development, 2002 , vol. 6, # 5 p. 628 - 631
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Citation Number: 7
Abstract
The synthesis of 3-methylalkane-2, 4-diones, which are intense strawlike and fruit-flavored compounds, has been performed by the aldol condensation of n-alkanal (C2-C7) and methyl ethyl ketone to give 4-hydroxy-3-methyl-2-alkanones in 31-72% yield, followed by oxidation using sodium hypochlorite in the presence of 4-benzoyloxy-2, 2, 6, 6-tetramethyl-piperidine- N-oxide in 60-86% yield.
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