Synthesis and application of bis-silylethyl-derived phosphate-protected Fmoc-phosphotyrosine derivatives for peptide synthesis

HG Chao, MS Bernatowicz, PD Reiss…

Index: Chao, Hann-Guang; Bernatowicz, Michael S.; Reiss, Paul D.; Matsueda, Gary R. Journal of Organic Chemistry, 1994 , vol. 59, # 22 p. 6687 - 6691

Full Text: HTML

Citation Number: 24

Abstract

Three Fmoc-phosphotyrosine derivatives with silylethyl-based phosphate protection were synthesized and evaluated for use in peptide synthesis." he stability of these derivatives toward piperidinel DMF (1: 4) treatment and their cleavability with TFA solutions were examined. On the basis of these data, the bis [(methyldiphenylsilyl) ethyll-protected Fmoc- phosphotyrosine derivative or Fmoc-Tyr (P03MDPSE&OH, was shown to be the most ...