Molecules

Synthesis of new bis-and tetra-acridines

V Sourdon, S Mazoyer, V Pique, JP Galy

Index: Sourdon, Valerie; Mazoyer, Stephane; Pique, Valerie; Galy, Jean-Pierre Molecules, 2001 , vol. 6, # 8 p. 673 - 682

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Citation Number: 30

Abstract

Acridine derivatives are well known therapeutic agents whose mutagenic properties depend on their ability to interact with nucleic acids. One mechanism of this interaction is the intercalation between the acridine moiety and the base pairs of the DNA helix.[1] Moreover the pharmacological activity of these intercalating drugs derives from their ability to inhibit the synthesis of nucleic acids by blocking the action of DNA metabolizing proteins.[2] To develop more effective ...

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