Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents

AN Matralis, MG Katselou, A Nikitakis…

Index: Matralis, Alexios N.; Katselou, Maria G.; Nikitakis, Anastasios; Kourounakis, Angeliki P. Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5583 - 5591

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Citation Number: 29

Abstract

Atherosclerosis is a multifactorial disease with several mechanisms participating in its manifestation. To address this disorder, we applied a strategy involving the design of a single chemical compound able to simultaneously modulate more than one target. We hereby present the development of novel benzoxazine and benzothiazine derivatives that significantly inhibit in vitro microsomal lipid peroxidation and LDL oxidation as well as ...

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