Tetrahedron letters

Synthesis of 7-cyano-and 7-acetamido-indoles via cyanocarbonation/hydrogenation of 7-formyl indole

SP Kolis, MT Clayton, JL Grutsch, MM Faul

Index: Kolis, Stanley P.; Clayton, Marcella T.; Grutsch, John L.; Faul, Margaret M. Tetrahedron Letters, 2003 , vol. 44, # 30 p. 5707 - 5710

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Citation Number: 12

Abstract

A procedure for the synthesis of 7-cyano and 7-acetamido indoles via cyanocarbonation/ hydrogenation of 7-formyl indole is presented. The process can be efficiently scaled up to provide multigram quantities of the desired compounds in good yield. A small survey of substrate scope indicates that the reaction may prove generally useful for the synthesis of aryl acetonitriles.

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