Chemistry Letters

Regioselective Formation of Optically Active Cycloheptatrienes by Chiral Tethered Buechner Reaction

T Sugimura, N Ohuchi, M Kagawa, K Hagiya…

Index: Sugimura, Takashi; Ohuchi, Naoko; Kagawa, Masami; Hagiya, Kazutake; Okuyama, Tadashi Chemistry Letters, 2004 , vol. 33, # 4 p. 404 - 405

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Citation Number: 8

Abstract

The chiral tethered reaction is a versatile reaction design for asymmetric synthesis where strict stereocontrol can be achieved during the reaction between reagent and substrate elements con- nected by a chiral 2,4-pentanediol (PD) tether.1 Chiral cyclohep- tatrienes in optically active forms became available by applying this reaction design to the Büchner reaction.2,3 The PD-tethered carbenoid addition with 1 is highly stereocontrolled to result in a quantitative ...