Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential

…, P Reddy, DR Reddy, E Laxman, YLN Murthy

Index: Kamal, Ahmed; Reddy; Reddy, D. Rajasekhar; Laxman; Murthy Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5699 - 5702

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Citation Number: 22

Abstract

There is a growing interest in agents, such as pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), that can recognize and bond to specific sequences of DNA. They are potential gene regulators with possible therapeutic applications in the treatment of genetic disorders, including some cancers, as selective antiinfective agents, and as probes and tools for use in molecular biology. 1 PBDs are a group of naturally occurring antitumor antibiotics, members of ...