Base??and Copper??Catalyzed Intramolecular Cyclization for the Direct Synthesis of Dihydrofurans

YF Chen, HF Wang, Y Wang, YC Luo…

Index: Chen, Yong-Fei; Wang, Hai-Fei; Wang, Ya; Luo, Yong-Chun; Zhu, Hai-Liang; Xu, Peng-Fei Advanced Synthesis and Catalysis, 2010 , vol. 352, # 7 p. 1163 - 1168

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Citation Number: 18

Abstract

Abstract A simple and convenient synthetic approach to dihydrofurans has been developed from the cyclization of 2-propynyl-1, 3-dicarbonyl compounds catalyzed by potassium tert- butoxide, copper (II) trifluoromethanesulfonate and triphenylphosphine using methanol/ dichloromethane as the solvent under very mild conditions. Moreover, dihydrofurans could be easily transformed into the corresponding furans in the presence of trifluoroacetic acid.