Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat

…, Y Fernandez, L Debrauwer, E Perdu…

Index: Alary, Jacques; Fernandez, Yvette; Debrauwer, Laurent; Perdu, Elisabeth; Gueraud, Francoise Chemical Research in Toxicology, 2003 , vol. 16, # 3 p. 320 - 327

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Citation Number: 57

Abstract

The formation of 4-hydroxy-2-nonenal (HNE) conjugates with glutathione (GSH) by Michael addition and subsequent cleavage to yield the related mercapturic acid (MA) conjugates are a major detoxication process. To characterize the metabolic pathways involved in the formation of urinary HNE-MA conjugates in the rat, the metabolism of HNE-thioethers (HNE- GSH, HNE-MA, and HNE-Cys) by rat liver and kidney cytosolic fractions was investigated. ...