Synthesis of 1-benzhydryl piperazine derivatives and evaluation of their ACE inhibition and antimicrobial activities

…, SN Kumar, P Sujitha, Y Poornachandra…

Index: Santhoshi, Amlipur; Kumar, Singam Naveen; Sujitha, Pombala; Poornachandra, Yedla; Sadhu, Partha Sarathi; Kumar, C. Ganesh; Rao, Vaidya Jayathirtha Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3207 - 3219

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Abstract

Abstract This study presents the synthesis of 14 new 1, 4-disubstituted piperazine derivatives from allyl bromides of Baylis–Hillman adduct and 4, 4-disubstituted benzhydryl piperazines. All the synthesized compounds were further screened for in vitro ACE inhibitor and antimicrobial activities. Among the synthesized piperazine derivatives, compound 12h showed moderate ACE inhibitor activity as compared to the standard, angiotensin- ...

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