Facile alcoholysis of L-lactide catalysed by Group 1 and 2 metal complexes

K Phomphrai, S Pracha, P Phonjanthuek…

Index: Phomphrai, Khamphee; Pracha, Supathana; Phonjanthuek, Phenphak; Pohmakotr, Manat Dalton Transactions, 2008 , # 23 p. 3048 - 3050

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Citation Number: 5

Abstract

Because lactic acid has both hydroxyl and carboxylic groups in the same molecule, intermolecular esterification can easily occur giving oligolactates. One way to solve this problem was to use a protecting group strategy. Early synthesis of alkyl lactyllactates was from the reaction of potassium lactate and ethyl 2-chloropropionate. However, this method was complicated and inconvenient. A better synthesis was later developed by Claborn using alcoholysis of ...