Glycosylation of a neoglycoprotein by using glycosynthase and thioglycoligase approaches: the generation of a thioglycoprotein

J Müllegger, HM Chen, RAJ Warren…

Index: Muellegger, Johannes; Chen, Hong Ming; Warren, R. Antony J.; Withers, Stephen G. Angewandte Chemie - International Edition, 2006 , vol. 45, # 16 p. 2585 - 2588

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Citation Number: 43

Abstract

Glycan structures, both intracellular and exposed on the surface of cells, play important roles in a large number of biological processes, such as cell–cell recognition, ligand–receptor binding, immunomodulation, and protein folding.[1, 2] Elucidation of the biological function of glycoproteins is currently hampered mainly by the fact that they are not easily available as homogenous isoforms but exist as complex mixtures of different glycoforms.[3, 4] As of yet, ...