Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs

JJ Chen, N Dewdney, X Lin, RL Martin…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 22 p. 3951 - 3954

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Citation Number: 13

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 11 A number of leads were identified from different chemical classes but most of them were rejected for lead optimization due to difficult synthesis and/or poor pharmacokinetic properties. Compound 1 (Fig. ...